人気ブログランキング | 話題のタグを見る

遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?

Arch Environ Contam Toxicol. 2007 May;52(4):596-602. Epub 2007 Mar 13.
New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity.

Séralini GE, Cellier D, de Vendomois JS.
Committee for Independent Information and Research on Genetic Engineering CRIIGEN, Paris, France. criigen@unicaen.fr

Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals.

One of these studies performed under the responsibility of Monsanto Company with a transgenic corn MON863 has been subjected to questions from regulatory reviewers in Europe, where it was finally approved in 2005.

This necessitated a new assessment of kidney pathological findings, and the results remained controversial.

An Appeal Court action in Germany (Münster) allowed public access in June 2005 to all the crude data from this 90-day rat-feeding study.

We independently re-analyzed these data. Appropriate statistics were added, such as a multivariate analysis of the growth curves, and for biochemical parameters comparisons between GMO-treated rats and the controls fed with an equivalent normal diet, and separately with six reference diets with different compositions.

We observed that after the consumption of MON863, rats showed slight but dose-related significant variations in growth for both sexes, resulting in 3.3% decrease in weight for males and 3.7% increase for females.

Chemistry measurements reveal signs of hepatorenal toxicity, marked also by differential sensitivities in males and females. Triglycerides increased by 24-40% in females (either at week 14, dose 11% or at week 5, dose 33%, respectively); urine phosphorus and sodium excretions diminished in males by 31-35% (week 14, dose 33%) for the most important results significantly linked to the treatment in comparison to seven diets tested.

Longer experiments are essential in order to indicate the real nature and extent of the possible pathology; with the present data it cannot be concluded that GM corn MON863 is a safe product.

PMID: 17356802 [PubMed - indexed for MEDLINE]



Transgenic Rootworm Corn: Assessing Potential Agronomic, Economic, and Environmental Benefits

How does Bt work?

Professor David Ellar: Genetics, biochemistry and regulation of virulence factors in bacilli pathogenic to humans and insects  etc.

遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_353434.gif


遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_327477.gif

「Kill Rootworm」だけですむのかどうか? 

遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_341336.jpg

遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_4104651.jpg

Bt Toxin (Bacillus thuringiensis)

遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_42264.jpg

                Bacillus thuringiensis

遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_23572639.jpg


遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_3313623.jpg

                BT毒素タンパク cry3Bb1

BT毒素はその名の通り、Bacillus thuringiensisの生産する毒素である。作用スペクトルの異なるいろいろな変種が知られている。古くから微生物農薬(殺虫剤)として、特に米国で使われていたが、殺虫作物とは、その毒素遺伝子を作物に組み込んでしまったわけである。当然、もはや洗っても落ちない。(しょうがない場合は?毒素をなるべく失活させるために、ちゃんと、加熱してから食べましょう!だけど、BT毒素のなかには耐熱性がかなり高くなかなか死なないものもあるようです。となると拒否するしかない。胃での分解は不完全のように思われるので。

遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_40567.gif


Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11908-12. Epub 2001 Sep 14. Links
Comment in:
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12328-30.
Effects of exposure to event 176 Bacillus thuringiensis corn pollen on monarch and black swallowtail caterpillars under field conditions.Zangerl AR, McKenna D, Wraight CL, Carroll M, Ficarello P, Warner R, Berenbaum MR.
Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

The widespread planting of corn genetically modified to produce Bacillus thuringiensis endotoxin has led to speculation that pollen from these fields might adversely affect nearby nontarget lepidopterans. A previous study of Bt corn engineered with Monsanto event 810 failed to detect an effect of pollen exposure on the black swallowtail, Papilio polyxenes, in either the field or the laboratory. Here, we report results of a field study investigating the impact of exposure to pollen from a Bt corn hybrid containing Novartis event 176 on two species of Lepidoptera, black swallowtails and monarch butterflies, Danaus plexippus. Nearly half of the 600 monarch larvae died within the first 24 h; this and subsequent mortality was not associated with proximity to Bt corn and may have been due in part to predation. Survivorship of black swallowtails was much higher than that of the monarchs and was also independent of proximity to the transgenic corn. However, despite five rainfall events that removed much of the pollen from the leaves of their host plants during the experiment, we observed a significant reduction in growth rates of black swallowtail larvae that was likely caused by pollen exposure. These results suggest that Bt corn incorporating event 176 can have adverse sublethal effects on black swallowtails in the field and underscore the importance of event selection in reducing environmental impacts of transgenic plants.

PMID: 11559837 [PubMed - indexed for MEDLINE]

(Erratum in: Plant J. 2001 Sep;27(6):483-8.)
Plant J 2002 Mar;29(5):679.
The monarch butterfly controversy: scientific interpretations of a phenomenon.Shelton AM, Sears MK.
Department of Entomology, Cornell University/NYSAES, Geneva, NY 14456, USA. ams5@cornell.edu
PMID: 11576433 [PubMed - indexed for MEDLINE]

Catastrophic Bee Population Decline May Be Related to Bt-Spliced GMO Crops

Bee Colony Collapse Disorder - Where is it Heading?

The Honeybee Crisis: Colony Collapse Disorder



遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_0171444.jpg



『Illuminati News』より(2)


Transgenic Res. 2007 Sep 13; [Epub ahead of print]
Impact of single-gene and dual-gene Bt broccoli on the herbivore Pieris rapae (Lepidoptera: Pieridae) and its pupal endoparasitoid Pteromalus puparum (Hymenoptera: Pteromalidae).
Chen M, Zhao JZ, Shelton AM, Cao J, Earle ED.
Department of Entomology, NYSAES, Cornell University, Geneva, NY, 14456, USA, ams5@cornell.edu.

Transgenic brassica crops producing insecticidal proteins from Bacillus thuringiensis (Bt) are being investigated as candidates for field release to control lepidopteran pests. Information on the potential impact of Bt brassica crops on pests and non-target natural enemies is needed as part of an environmental risk assessment prior to the commercial release. This first tier study provides insight into the tritrophic interactions among Bt broccoli plants, the herbivore Pieris rapae and its parasitoid Pteromalus puparum. We first evaluated the efficacy of three types of Bt broccoli plants, cry1Ac, cry1C and cry1Ac + cry1C, on different instars of P. rapae. Bt broccoli effectively controlled P. rapae larvae, although later instars were more tolerant. The efficacy of different Bt broccoli plants on P. rapae larvae was consistently cry1Ac > cry1Ac + cry1C > cry1C. When the parasitoid P. puparum developed in a P. rapae pupa (host) that had developed from Bt plant-fed older larvae, developmental time, total number and longevity of the P. puparum generated from the Bt plant-fed host were significantly affected compared with those generated from the non-Bt control plant-fed host. Simultaneously, negative effects on P. rapae pupae were found, i.e. pupal length, width and weight were significantly reduced after older P. rapae larvae fed on different Bt plants for 1 or 2 days. Cry1C toxin was detected using ELISA in P. rapae pupae after older larvae fed on cry1C broccoli. However, no Cry1C toxin was detected in newly emerged P. puparum adults developing in Bt-fed hosts. Only a trace amount of toxin was detected from entire P. puparum pupae dissected from the Bt plant-fed host. Moreover, no negative effect was found on the progeny of P. puparum developing from the Bt plant-fed host when subsequently supplied with a healthy host, P. rapae pupae. The reduced quality of the host appears to be the only reason for the observed deleterious effects on P. puparum. Our data suggest that the effects on P. puparum developing in Bt plant-fed P. rapae are mediated by host quality rather than by direct toxicity.

PMID: 17851777 [PubMed - as supplied by publisher]

遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_119944.jpg



遺伝子組み換えとうもろこし モンサント MON863=肝腎毒=毒素攻撃?_c0139575_0154185.jpg

Kristen Philipkoski 2004年05月24日

























by oninomae | 2007-10-06 02:38 | バイオハザード・GMO食品  

<< 破局的な蜂の個体群減少はBt遺... 今日も元気か?プロザック >>