Australia bans flu vaccines in children after vomiting, fevers, seizures by Mike Adams Friday, August 27, 2010
Finland suspends H1N1 vaccines after children suffer narcolepsy from vaccinations by Mike Adams Saturday, August 28, 2010
超要約： ナルコレプシーは、自己免疫疾患で、ペプチドホルモンであるオレキシン（ヒポクレチン）を生産する細胞が攻撃され死んでいくと起こるようです。 ワクチンによる自己免疫誘導は、よく知られていることであり、上記の記事のようなことは、あるだろうなと思われます。
Minister Calls for Thorough Examination of Possible Link Between H1N1 and Narcolepsy
http://yle.fi/uutiset/news/2010/08/minister_calls_for_thorough_examination_of_possible_link_between_h1n1_and_narcolepsy_1912099.html published Aug 18 01:09 PM, updated Aug 20 10:24 AM
Minister of Health and Social Services Paula Risikko says it is essential to thoroughly examine suspicions that increased outbreaks of child narcolepsy might be linked to the H1N1 swine flu vaccine.
However, the Minister said the swine flu vaccination programme would continue. In her view, Risikko thought it wise to examine any connection between narcolepsy and swine flu vaccine in other European countries.
The National Institute for Health and Welfare (THL) is to determine if vaccine for the H1N1 swine flu could be linked to an increase in cases of narcolepsy among children.
The condition causes excessive daytime sleepiness even after adequate nocturnal sleep.
Although the THL’s Vaccine Department Director Terhi Kilpi does not fear any connection between the H1N1 jab and narcolepsy, she says doubts must be examined.
Experts on both vaccines and narcolepsy met on Wednesday to discuss the issue.
Doubts arose when a Finnish child neurologist noticed an increased level in the number of narcolepsy cases this year. Similar observations have been noticed in Sweden, reports the tabloid Iltalehti.
Medical officials in Sweden are also examining a possible link between the Pandemrix vaccine and narcolepsy, according to the newspaper Svenska Dagbladet. The Swedish news agency TT reports six cases with a possible link to the vaccine.
A patient suffering from narcolepsy may suddenly fall asleep, for example, while, speaking or eating without prior warning. Their muscles may also suddenly weaken, causing them to suddenly collapse. There is no known cure for the disease.
Several Times Normal Rate of Cases
About a dozen Finnish children fell ill with narcolepsy during or after last winter's swine flu epidemic, far more than the average rate. The THL is trying to determine whether the cases may have been related to the H1N1 vaccine or to the flu itself.
The cases were diagnosed during the spring and early summer. Dr Markku Partinen, a docent in neurology at the University of Helsinki and former president of the World Association of Sleep Medicine, notes that the cases appear to have a chronological link to the H1N1 epidemic.
Doctors began to wonder when an unusually large number of cases of narcolepsy began to appear last spring.
“When it became clear that the symptoms began to appear in December, January and February, we began to consider a link to the swine flu epidemic,” says Partinen.
So far about 12-14 cases have been detected, all with symptoms that began between December and February, says Partinen. The patients are aged 5 to 15.
On average about three cases of the illness are diagnosed in Finland annually.
Narcolepsy confirmed as autoimmune disorder by Katie Lee Wednesday, 6 May 2009
BRISBANE: Narcolepsy is caused by a confused immune system destroying hormone-producing cells in the brain, says a new study.
Sufferers of the disabling sleep disorder – who suffer from sudden and frequent bouts of daytime sleepiness – often have a unique version of the immune-related gene TCR-alpha, report researchers this week in the journal Nature Genetics.
TCR-alpha codes for a receptor that identifies foreign proteins in the body and triggers the immune system to attack.
An unusual form of that receptor may lead the immune system to mistakenly recognise parts of the brain as foreign, leading it to attack them, said lead author Emmanuel Mignot a sleep researcher at Stanford University in Palo Alto, California.
"An autoimmune etiology has been suggested for narcolepsy but never proven [before now] despite decades of intensive research," he said.
Narcolepsy is caused by a lack of cells in the brain that produce hypocretin, a hormone that helps regulate the sleep-wake cycle. In the 1980s it was discovered that narcolepsy was also strongly associated with unique variants of the gene HLA-DQB1*0602.
This gene codes for a protein that presents foreign proteins to the immune system, which becomes activated to destroy pathogens carrying those proteins. Researchers have long suspected that having a variant version of the gene predisposes people to an autoimmune reaction against hypocretin-producing cells.
However, not everyone with HLA-DQB1*0602 variants has narcolepsy, so Mignot's team scanned the entire genome of more than 4,000 people who have the variant gene, to find other genes associated with narcolepsy. The people who did have narcolepsy were 20 times more likely to also have a variant TCR-alpha gene, Mignot's team found.
"Both sides of the story"
TCR-alpha receptors found on the T-cells of the immune system, work closely with HLA proteins to recognise and destroy cells that have been identified as foreign. This strongly suggests that the two variant proteins working together can turn the immune system against hypocretin-producing cells, causing narcolepsy.
The discovery means that it might be possible to prevent narcolepsy by blocking the variant proteins, so they can't trigger the destruction of hypocretin-producing cells.
Gethin Thomas, an immunologist at the University of Queensland in Brisbane, Australia, said the research was important because, while HLA proteins were known to be involved in dozens of autoimmune diseases, it was the first time anyone had found both a HLA protein and a T-cell receptor linked to an autoimmune disease. "They've found both sides of the story," he said.